One theory is that herpesviruses cooperate with specific bacteria in the etiopathogenesis of the disease.  Aggressive periodontitis is often characterised by a rapid loss of periodontal attachment associated with highly pathogenic bacteria and an impaired immune response. Three-walled or intrabony defect is the ideal defect for bone grafts and has a better success rate compared to a two-walled and one-walled defect. However, with the exponential rate of developments in periodontal research, regenerative therapy, tissue engineering, and genetic technologies, the future seems promising in regard to options at managing the disease. The American Academy of periodontology revised the classification of periodontal diseases in 1999. For example, periodontitis is linked with respiratory disease, rheumatoid arthritis, coronary artery disease and problems controlling blood sugar in diabetes. A preprocedural rinse with antimicrobial agent was done to minimize the bacterial count in the mouth. Aggressive periodontitis (AgP) is a form of periodontitis characterized by rapid and severe periodontal destruction in otherwise young healthy individuals. Some experts believe that aggressive periodontitis is caused by the bacterium Aggregatibacter actinomycetemcomitans. View at: Google Scholar See in References , 2 1. The patient was advised to follow a modified Stillman technique of brushing since the patient had root exposure and hypersensitivity and also advised to use interdental brushes and dental floss for optimal plaque control. Whether the subgingival microbiota differ between individuals with chronic and those with aggressive periodontitis, and whether smoking influences bacterial composition, is controversial. We hypothesized that the subgingival microbiota do not differ between sites in individuals with chronic or aggressive periodontitis, or by smoking status. All together there were minimal signs of inflammation other than bleeding on probing. The oral hygiene status of the patient was good as revealed by the oral hygiene index. 4 This disease process is now associated with a specific pathogen, Aggregatibacter actinomycetemcomitans (formerly Actinobacillus). bacteria to multiply and also the addition of the pro inflammatory mediators to cause periodontal destruction and eventually tooth loss. GAP responds well to SRP in short term (upto 6 months). The disease is generally found to have a racial and sex predilection, with blacks and male teenagers having higher risk for the disease compared to whites and females, although reports vary between different ethnic groups and populations, with some populations showing prevalence as high as 28.8% [4, 5]. Aggressive periodontitis can be differentiated from chronic periodontitis by the age of onset, rapid rate of disease progression, the nature and composition of the associated subgingival microflora, alterations in host immune response, and a familial aggregation of the diseased individuals . A full-mouth periodontal charting revealed generalized periodontal pockets and clinical attachment loss (Figure 6). Associations between serum antibody levels to periodontal pathogens and early-onset periodontitis. It is a multifactorial disease where interplay of microbiologic, genetic, immunologic, and environmental/behavioral risk factors decides the onset, course, and severity. A thorough supragingival scaling was performed following which the patient was motivated for better plaque control. In its early stage, called gingivitis, the gums become swollen, red, and may bleed. The graft was a xenograft (Bovine graft—Ossopan), which was mixed with the blood from the surgical site and placed into the defect after presuturing the site with silk sutures. There was grade I mobility of 22, 31, 32, 21 and 22. Allografts used for periodontal grafts include mineralized freeze-dried bone allografts (FDBAs) which are osteoconductive, and decalcified freeze-dried bone allografts (DFDBAs) which are osteoinductive. There was grade I mobility of 15 and 22 and grade II mobility of 11, 12, 21, 31, 32, 33 and 42. Although its prevalence has been reported to be much less than that of chronic periodontitis, it can result in early tooth loss in the affected individuals if not diagnosed in the early stages and treated appropriately . Another approach to mechanical antimicrobial therapy is a one-stage full mouth disinfection therapy devised by Quirynen et al., which was found to result in an improved clinical outcome and microbial improvement in early onset periodontitis compared to quadrant-wise SRP [38, 39]. B. Novaes, and M. Taba Jr., “Antimicrobial photodynamic therapy in the non-surgical treatment of aggressive periodontitis: a preliminary randomized controlled clinical study,”, J. J. Kamma, V. G. S. Vasdekis, and G. E. Romanos, “The effect of diode laser (980 nm) treatment on aggressive periodontitis: evaluation of microbial and clinical parameters,”, A. D. Haffajee, S. S. Socransky, and J. C. Gunsolley, “Systemic anti-infective periodontal therapy. Aggressive periodontitis is a disease much like the high blood pressure and diabetes which, whilst unfortunately cannot be completely cured, can be controlled and managed exceptionally well with medical treatment and specialist after care. A. Jansen, and N. H. J. Creugers, “Effect of platelet-rich plasma on bone regeneration in dentistry: a systematic review,”, S. Yilmaz, G. Cakar, B. E. Kuru, and B. Yildirim, “Platelet-rich plasma in combination with bovine derived xenograft in the treatment of generalized aggressive periodontitis: a case report with re-entry,”, J. J. Kamma and P. C. Baehni, “Five-year maintenance follow-up of early-onset periodontitis patients,”, L. Q. Closs, S. C. Gomes, R. V. Oppermann, and V. Bertoglio, “Combined periodontal and orthodontic treatment in a patient with aggressive periodontitis: a 9-year follow-up report,”, L. A. Harpenau and R. L. Boyd, “Long-term follow-up of successful orthodontic-periodontal treatment of localized aggressive periodontitis: a case report,”, J. Even though the prevalence of aggressive periodontitis is much lower than chronic periodontitis, the management of aggressive periodontitis is more challenging compared to that of chronic periodontitis because of its strong genetic predisposition as an unmodifiable risk factor. The patient was put on regular recall appointments for evaluation of the gingival and periodontal status and maintenance therapy. Periodontal disease, also known as gum disease, is a set of inflammatory conditions affecting the tissues surrounding the teeth. With further understanding of the genetic risk factors, a futuristic application of genetic screening tests will be in identifying the susceptible individuals and instituting the preventive measures to keep the gene expression and thus the disease under control [105, 106]. Generalized aggressive periodontitis affects almost all of the patient’s teeth. 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